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. 2020 Oct 20;11(10):880. doi: 10.1038/s41419-020-03069-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Hippo-YAP axis regulates autophagy and affects the development of disease progression. Inhibition of disease progression (beneficial process) is shown in blue, whereas promotion of disease progression (harmful process) is shown in red. In many diseases, autophagy clears dysfunctional mitochondria and protein aggregates. As two conserved signaling pathways, the Hippo pathway and autophagy intersect in the regulation of cell death and proliferation, tumorigenesis, and survival and growth of tumor cells. ALS, amyotrophic lateral sclerosis; DCM, diabetic cardiomyopathy; HCC, hepatocellular carcinoma; I/R, ischemia-reperfusion; NAFLD, non-alcoholic fatty liver disease; PTC, papillary thyroid carcinoma; SCI, spinal cord injury; TSC, tuberous sclerosis complex.