Table 2.

Small molecules or drugs that target the Hippo core components autophagy regulatory network.

Organ		Diseases	Small molecules or drugs	Effects	Reference
	Brain	SAH	Melatonin	Melatonin play a neuroprotective role by regulating the homeostasis between apoptosis and autophagy through the oxygen species (ROS)-MST1 pathway	Shi et al.134
		Glioblastoma	Silibinin	Silibinin induced glioblastoma cell apoptosis and autophagy via inhibition of mTOR and YAP.	Bai et al.110
	Heart	DCM	Melatonin	Melatonin protects against DCM by increasing autophagy and reducing apoptosis through MST1/Sirt3 signaling	Zhang et al.131
		Cardiotoxicity	Adriamycin	HMGB1 is functionally related to YAP and participates in adriamycin-induced cardiotoxicity by upregulating autophagy.	Luo et al.129
	Liver	HCC	Sorafenib	Sorafenib promotes autophagy and is the standard treatment for advanced HCC, LATS1 restricts lethal autophagy in sorafenib-induced HCC cells.	Tang et al.119
		Hepatic fibrosis	Dihydrotanshinone I	Dihydromorphone I exerts anti-fibrotic effects by blocking the YAP-TEAD2 complex and stimulating autophagy	Ge et al.123
	Pancreas	Pancreatic cancer	Neratinib	Neratinib degrades MST4 via autophagy and is essential for the inactivation of YAP/TAZ.	Dent et al.118
	Colon	Colon cancer	Curcumin	Curcumin induces autophagy via inhibition of YAP.	Zhu et al.109
		Colon cancer	Shikonin	Shikonin effectively suppress colon cancer cell viability and migration, and induces autophagy via inhibiting the activity of YAP.	Zhu et al.112

DCM diabetic cardiomyopathy, HCC hepatocellular carcinoma, SAH subarachnoid hemorrhage.