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. 2020 Oct 20;11:5290. doi: 10.1038/s41467-020-18974-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — At left, single-subject waveforms of periodic breathing in opioid use, stroke, heart failure, at high altitude, and in newborns. These are all conditions and situations in which periodic breathing is commonly encountered. At right, illustrations of bursts in 11 HCP subjects. All plots are on the same time scale, and the green lines measure 1 min. Note the long cycle times seen in patients with heart failure (in the Stroke and Heart failure sections), reflecting, in part, an exaggerated delay in central detection of changes in arterial gas tensions (see Supplementary Discussion for more detail). The stroke example illustrates shows the added effect of delayed circulatory time in heart failure. Images at left modified from^46,54–58 with permission. Images from ref. ⁵⁵ adapted with the permission of the American Thoracic Society. Copyright © 2020 American Thoracic Society. All rights reserved. The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society. Readers are encouraged to read the entire article for the correct context at https://europepmc.org/article/med/15665317. The authors, editors, and The American Thoracic Society are not responsible for errors or omissions in adaptations.