TABLE 3.
Crude and adjusted hazard ratios of fractures according to trajectories of benzodiazepine (BZD) dispensing in people aged 50 years or older and those aged 75 years or older—joint latent class model estimates (permanent sample of beneficiaries 2009–2016—n = 106 437)
| ≥50 y at inclusion (n = 106 437) | ≥75 y at inclusion (n = 21 852) | |||
|---|---|---|---|---|
| Trajectories of BZD dispensing (ref. non‐users) | Crude hazard ratios with 95% CI | Adjusted hazard ratios a with 95% CI | Crude hazard ratios with 95% CI | Adjusted hazard ratios a with 95% CI |
| Occasional users | 0.91 0.83–0.99 | 0.99 0.99–1.00 | 1.00 0.99–1.00 | 1.00 0.99–1.00 |
| Decreasing users | 0.92 0.85–0.99 | 0.90 0.74–1.08 | 0.88 0.67–1.15 | 0.92 0.68–1.28 |
| Early increasing users | 3.35 2.96–3.79 | 1.86 1.62–2.14 | 2.08 1.73–2.50 | 1.87 1.53–2.27 |
| Late increasing users | 3.04 2.63–3.52 | 1.36 1.15–1.60 | 1.92 1.58–2.33 | 1.81 1.47–2.23 |
a
survival model adjusted on: age at inclusion, sex, drugs dispensed during follow‐up and long‐term diseases (see Supplementary Table S2), somatic multimorbidity score (see Supplementary Table S3).
CI: confidence interval.