. 2020 Sep 10;9(10):978–998. doi: 10.1530/EC-20-0423
This work is licensed under a Table 2.
Changes in metabolic outcomes after use of oral contraceptives containing different progestins, by study duration.
| Outcome | Subgroup (months) | N studies (participants) | pMD (95% CI) | I2 | P-value for difference between subgroups | P-value for heterogeneity |
|---|---|---|---|---|---|---|
| Cyproterone | ||||||
| BMI | <12 | 14 (300) | −0.13 (−0.45, 0.19) | 0 | 0.35 | 0.66 |
| ≥12 | 2 (50) | 0.23 (−0.46, 0.92) | 0 | 0.84 | ||
| Glucose | <12 | 11 (233) | −1.63 (−3.11, −0.16) | 11 | 0.64 | 0.34 |
| ≥12 | 2 (50) | −3.11 (−9.09, 2.87) | 97 | <0.0001 | ||
| TG | <12 | 18 (347) | 23.7 (15.6, 31.9) | 80 | 0.49 | <0.0001 |
| ≥12 | 6 (213) | 32.6 (8.9, 56.2) | 96 | <0.0001 | ||
| HDL | <12 | 18 (347) | 6.87 (2.64, 11.1) | 93 | 0.94 | <0.0001 |
| ≥12 | 4 (133) | 6.55 (−0.56, 13.7) | 81 | 0.0002 | ||
| LDL | <12 | 18 (347) | −3.07 (−7.83, 1.69) | 66 | 0.002 | <0.0001 |
| ≥12 | 5 (179) | 11.7 (3.34, 20.2) | 61 | 0.04 | ||
| HOMA | <12 | 9 (216) | −0.32 (−0.85, 0.22) | 97 | 0.64 | <0.0001 |
| ≥12 | 1 (26) | −0.55 (−1.39, 0.29) | NA | NA | ||
| Chlormadinone | ||||||
| BMI | <12 | 1 (12) | 0.20 (−2.45, 2.85) | NA | 0.87 | NA |
| ≥12 | 1 (20) | 0.50 (−2.10, 3.10) | NA | NA | ||
| Glucose | <12 | 1 (12) | 0 (−4.04, 5.04) | NA | 0.28 | NA |
| ≥12 | 1 (20) | −4.20 (−10.01, 1.61) | NA | NA | ||
| TG | <12 | 1 (12) | 23.0 (5.80, 40.2) | NA | 0.12 | NA |
| ≥12 | 1 (20) | 56.7 (17.6, 95.8) | NA | NA | ||
| HDL | <12 | 1 (12) | 12.3 (1.01, 23.6) | NA | 0.60 | NA |
| ≥12 | 1 (20) | 8.90 (3.22, 14.6) | NA | NA | ||
| LDL | <12 | 1 (12) | −7.70 (−32.9, 17.5) | NA | 0.53 | NA |
| ≥12 | 1 (20) | −0.76 (−13.7, 12.1) | NA | NA | ||
| HOMA | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| Desogestrel | ||||||
| BMI | <12 | 6 (196) | 0.11 (−0.45, 0.67) | 0 | 0.16 | 0.79 |
| ≥12 | 2 (15) | 2.20 (−0.67, 5.07) | 0 | 0.99 | ||
| Glucose | <12 | 9 (281) | 1.53 (−0.56, 3.61) | 58 | – | NA |
| ≥12 | – | NA | NA | NA | ||
| TG | <12 | 18 (451) | 25.9 (18.6, 33.2) | 74 | 0.40 | <0.0001 |
| ≥12 | 4 (86) | 33.1 (18.0, 48.2) | 71 | 0.008 | ||
| HDL | <12 | 19 (481) | 6.69 (4.94, 8.45) | 33 | 0.73 | 0.08 |
| ≥12 | 7 (102) | 7.63 (2.72, 12.5) | 52 | 0.05 | ||
| LDL | <12 | 18 (465) | 0.19 (−4.37, 4.75) | 58 | 0.001 | |
| ≥12 | 9 (117) | 22.3 (5.66, 38.9) | 80 | <0.0001 | ||
| HOMA | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| Drospirenone | ||||||
| BMI | <12 | 5 (146) | −0.07 (−0.87, 0.73) | 0 | 0.25 | 0.96 |
| ≥12 | 4 (128) | −0.69 (−1.04, −0.16) | 0 | 0.58 | ||
| Glucose | <12 | 7 (223) | 0.27 (−2.36, 2.90) | 76 | 0.37 | 0.0003 |
| ≥12 | 2 (271) | 4.71 (−4.60, 14.01) | 98 | <0.0001 | ||
| TG | <12 | 6 (173) | 24.0 (12.4, 35.6) | 61 | 0.06 | 0.03 |
| ≥12 | 9 (479) | 38.9 (28.4, 49.4) | 92 | <0.0001 | ||
| HDL | <12 | 8 (252) | 7.91 (4.11, 11.7) | 67 | 0.78 | 0.003 |
| ≥12 | 9 (479) | 7.21 (4.12, 10.3) | 82 | <0.0001 | ||
| LDL | <12 | 8 (252) | −2.96 (−9.71, 3.80) | 62 | 0.04 | 0.01 |
| ≥12 | 9 (479) | 6.30 (0.56, 12.0) | 84 | <0.0001 | ||
| HOMA | <12 | 5 (146) | −0.16 (−0.61, 0.28) | 60 | 0.64 | 0.04 |
| ≥12 | 6 (172) | 0.10 (−0.91, 1.11) | NA | NA | ||
| Gestodene | ||||||
| BMI | <12 | 2 (38) | 0.56 (−0.50, 1.63) | 0 | 0.47 | 0.64 |
| ≥12 | 1 (71) | 0.10 (−0.56, 0.76) | NA | NA | ||
| Glucose | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| TG | <12 | 12 (281) | 25.7 (21.1, 30.3) | 0 | 0.79 | 0.69 |
| ≥12 | 3 (114) | 28.0 (11.2, 44. 9) | 77 | 0.01 | ||
| HDL | <12 | 13 (273) | 1.39 (−0.03, 2.81) | 2 | 0.53 | 0.43 |
| ≥12 | 3 (114) | 2.80 (−1.39, 7.00) | 42 | 0.18 | ||
| LDL | <12 | 9 (245) | −3.24 (−6.88, 0.40) | 2 | 0.37 | 0.42 |
| ≥12 | 3 (359) | −1.01 (−4.20, 2.18) | 0 | 0.64 | ||
| HOMA | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| Levonorgestrel | ||||||
| BMI | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| Glucose | <12 | 5 (199) | −3.0 (−11.1, 5.09) | 87 | 0.35 | <0.0001 |
| ≥12 | 4 (296) | −8.16 (−15.3, −0.99) | 88 | <0.0001 | ||
| TG | <12 | 25 (650) | 13.7 (9.42, 17.9) | 41 | 0.26 | 0.02 |
| ≥12 | 13 (456) | 9.02 (2.06, 16.0) | 64 | 0.0008 | ||
| HDL | <12 | 28 (707) | −4.19 (−5.73, −2.66) | 58 | 0.59 | <0.0001 |
| ≥12 | 11 (407) | −4.94 (−7.18, −2.70) | 31 | 0.15 | ||
| LDL | <12 | 16 (496) | 5.08 (2.42, 7.75) | 0 | 0.04 | 0.49 |
| ≥12 | 13 (456) | 10.2 (6.15, 14.2) | 21 | 0.23 | ||
| HOMA | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| Norgestimate | ||||||
| BMI | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| Glucose | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| TG | <12 | 5 (98) | 36.3 (28.3, 44.2) | 56 | 0.04 | 0.06 |
| ≥12 | 1 (25) | 27.3 (23.9, 30.7) | NA | NA | ||
| HDL | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA | ||
| LDL | <12 | 4 (81) | 9.02 (5.73, 12.3) | 0 | 0.0002 | 0.86 |
| ≥12 | 1 (25) | 17.8 (14.6, 20.8) | NA | NA | ||
| HOMA | <12 | – | NA | NA | – | NA |
| ≥12 | – | NA | NA | NA |
NA, not applicable, heterogeneity not calculable in this subgroup; NR, not reported.