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. 2020 Oct 7;8:590549. doi: 10.3389/fbioe.2020.590549

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Copyright © 2020 Qu, Chen, Shu, Tian, Ou, Zhang, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental methods for 3D printing spinal cord scaffold. (A) Schematic of the anatomical structure of spinal cord in cross section showing gray matter, along with the white matter periphery, and the 3D-printed multichannel scaffold for modeling the spinal cord. (B) Schematic diagram of the layer-by-layer 3D printing process. (C) Comparative photograph of rat spinal cord cross-section and multi-channel 3D printing spinal cord scaffold. The number of channels could be adjusted according to the size of the required bracket. A top view (D) and the side view (E) of the scaffold. (F) A 2 mm × 2 mm × 5 mm sized scaffold on top of a finger showed the scale of the scaffold. Reproduced with permission from Joung et al. (2018).