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. 2020 Oct 21;17:311. doi: 10.1186/s12974-020-01991-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Resveratrol reverses mechanical allodynia in SNI rats via enhancing TREM2-mediated autophagy. a Schematic of experimental procedures. b Representative Western blots and quantification of TREM2 in the ipsilateral SDH at 7 days in the Sham, SNI, and SNI + Lv-TREM2 rats. c The mRNA level of TREM2 in the ipsilateral SDH at 7 days in the Sham, SNI, and SNI + Lv-TREM2 rats. d, e The mechanical allodynia of the contralateral (d) and ipsilateral side (e) was detected by von Frey test at indicated time points in SNI, SNI + Res, SNI + Res + Lv-TREM2, SNI + Res + 3-MA, and SNI + Res + Lv-TREM2 + 3-MA group. Data were presented as mean ± SEM. n = 5 rats per group. The same color represented the same group. ***p < 0.001 vs. SNI + Res group, &&&p < 0.001 vs. SNI + Res + Lv-TREM2 group, ###p < 0.001 vs. SNI + Res + 3-MA. $p < 0.05 vs. SNI + Res + Lv-TREM2. f The 50% PWT in the ipsilateral side on day 7 from the five groups shown in (e). Data were presented as mean ± SEM. n = 6 rats per group; ***p < 0.001, **p < 0.01 vs. SNI group, &&&p < 0.001 vs. SNI + Res group, ###p < 0.001 vs. SNI + Res. $p < 0.05 vs. SNI + Res + Lv-TREM2