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. 2020 Oct 21;17:312. doi: 10.1186/s12974-020-01995-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effect of LPS-RS injection into the trigeminal ganglion in rats with tooth pulp inflammation. a Time course of the experimental procedure for the group administered LPS-RS into the trigeminal ganglion immediately preceding head withdrawal threshold measurement in rats with tooth pulp exposure (Tooth pulp exposure + Immediate LPS-RS). b Time course of the experimental procedure for the groups administered vehicle or LPS-RS into the trigeminal ganglion of rats with sham or tooth pulp exposure procedures. c The head withdrawal threshold to heat or mechanical stimulation of the ipsilateral tongue following administration of vehicle or LPS-RS into the trigeminal ganglion of rats with sham or tooth pulp exposure procedures. The two-way repeated-measures ANOVA followed by Tukey–Kramer post hoc tests were used to compare head withdrawal thresholds between groups. d Fluorogold-labeled IL-1RI-IR cells in the trigeminal ganglion following administration of vehicle or LPS-RS into the trigeminal ganglion of rats with sham or tooth pulp exposure procedures. The arrowheads indicate fluorogold-labeled IL-1RI-IR cells. Scale bar, 100 μm. e The number of each IR cell type in the trigeminal ganglion of the third branch region was calculated by using the following formula: fluorogold-labeled IL-1RI-IR cells/fluorogold-labeled cells × 100%. The one-way repeated-measures ANOVA followed by Tukey–Kramer post hoc test was employed for the comparison of the percentages of positive cells between groups. Data are expressed as the mean ± SEM