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. 2020 Oct 21;39:223. doi: 10.1186/s13046-020-01735-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Upregulated YTHDF2 promotes the inhibited proliferation, invasion and migration while diminishing the augmented cell apoptosis evoked by miR-495 in PCa cells. a, miR-495 expression in cells following varied transfection detected by RT-qPCR. b, The mRNA expression of YTHDF2 in cells following varied transfection detected by RT-qPCR. c, Western blots of YTHDF2 protein in cells following varied transfection. d, PC3 cell proliferation following varied transfection measured by Colony formation assay. e, PC3 cell apoptosis following varied transfection measured by flow cytometry. f, PC3 cell invasion following varied transfection measured by Transwell assay. Scale bar = 50 μm. g, PC3 cell migration following varied transfection measured by Scratch test. * p < 0.05 vs. cells transfected with mimic NC + oe-NC. # p < 0.05 vs. cells transfected with miR-495 mimic + oe-NC. ^ns p > 0.05 vs. cells transfected with mimic NC + oe-NC or miR-495 mimic + oe-NC. Data in panel A-G were analyzed by one-way ANOVA with Tukey’s post hoc test