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. 2020 Oct 20;10:17802. doi: 10.1038/s41598-020-74836-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Valproic acid decreases IFN-γ serum levels during Listeria monocytogenes infection in vivo. BALB/c mice were treated with VPA (500 mg/Kg) or s.s 15 min before infection with 2.5 × 10⁵ CFU L.m i.p. 24 and 48 hpi the cytokines (A) IFN-γ (***P < 0.001, VPA + L.m vs s.s + L.m groups at 24 and 48 hpi), (B) TNF-α (*P < 0.05, VPA + L.m vs s.s + L.m groups at 48 hpi), (C) IL-12p70 and (D) IL-10 were evaluated in serum by ELISA. (n = 11 per group; N. S., Not Significant). Data are expressed as median and range; Kruskal–Wallis.