Table 2.
Cytoplasmic and extra cellular matrix (ECM) Talin1 expression (Intensity of staining, percentage of positive tumor cells, and H-score in FFPE colorectal cancer (CRC) and adjacent normal tissues.
| Scoring system | Cytoplasmic expression N (%) | ECM expression N (%) | ||
|---|---|---|---|---|
| CRC samples | Adjacent normal tissues | CRC samples | Adjacent normal tissues | |
| Intensity of staining | ||||
| Negative (0) | 5 (0.8) | 24 (35.8) | 20 (3.1) | 10 (14.9) |
| Weak (+ 1) | 187 (28.9) | 33 (49.3) | 189 (29.2) | 50 (74.6) |
| Moderate (+ 2) | 361 (55.7) | 3 (4.5) | 404 (62.3) | 0 (0.0) |
| Strong (+ 3) | 95 (14.7) | 0 (0.0) | 35 (5.4) | 0 (0.0) |
| Not identified | 0 (0.0) | 7 (10.4) | 0 (0.0) | 7 (10.4) |
| Percentage of positive tumor cells | ||||
| < 25% | 18 (2.8) | 0 (0.0) | 30 (4.6) | 0 (0.0) |
| 25–50% | 25 (3.9) | 0 (0.0) | 51 (7.9) | 1 (1.5) |
| 51- 75% | 156 (24.1) | 6 (9.0) | 162 (25.0) | 11 (16.4) |
| > 75% | 449 (69.3) | 54 (80.6) | 405 (62.5) | 48 (71.6) |
| Not identified | 0 (0.0) | 7 (10.4) | 0 (0.0) | 7 (10.4) |
| H-score (3 groups) | ||||
| 0–100 | 205 (31.6) | 25 (37.3) | 235 (36.3) | 11 (16.4) |
| 101–200 | 349 (53.9) | 32 (47.8) | 379 (58.5) | 49 (73.1) |
| 201–300 | 94 (14.5) | 3 (4.5) | 34 (5.2) | 0 (0.0) |
| Not identified | 0 (0.0) | 7 (10.4) | 0 (0.0) | 7 (10.4) |
| Total | 648 (100) | 67 (100) | 648 (100) | 67 (100) |
H-score indicates Histological score.