Fig. 7. Paratope states of the SPE7 antibody including the results of the Markov-state model and shows the relative VH − VL interface distributions for the respective macrostates.
a Combined free energy landscape of all CDR loops with the respective three macrostate representatives. b Markov-state model, transition kinetics, and state probabilities of different paratope states for the SPE7 antibody. c Relative VH–VL interface dynamics of the macrostate ensembles, color-coded according to the Markov-state model in (b). The horizontal line depicts the interface orientation of the crystal structure.