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. 2020 Oct 20;53:48. doi: 10.1186/s40659-020-00316-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The effect of daphnetin on skin lesion in IMQ-induced psoriasis-like mouse model. a The macroscopic appearance of mouse back skin on day 8. b Erythema and (c) scaling was scored on days 0, 2, 4, and 7 based on the PASI. d H&E staining of the mouse skin. Bar, 100 μm. e Epidermal thickness was calculated by Image-pro Plus 6.0 software. ***P < 0.001. f qRT-PCR was performed to measure the expression of KRT6 in skin lesion. GAPDH served as an internal reference. *P < 0.05. **P < 0.01. g Dermal cellular infiltrates were quantitated with H&E staining images. *P < 0.05. ***P < 0.001