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Targeting more than one antigen receptor approaches. (A) Coadministration-producing two separate CAR-T cell products and infusing together or sequentially. (B) Bicistronic CAR-using a single vector that encodes two or three different CARs on a single T cell. (C) Tandem CAR-encoding two CARs on same chimeric protein using a single vector.
CAR, chimeric antigen receptor.
