Table 1.
Evaluated characteristics of patients with severe COVID-19 infection
| Total | IVIg Group | Control Group | P-value$ | |
|---|---|---|---|---|
| Age (years)a | 56 (46,62) | 55.5 (45,60) | 56 (47,66) | 0.375 |
| Sex n (%) | ||||
| Male | 41 (69.5) | 21 (70) | 20 (68.9) | 0.931 |
| Female | 18 (30.5) | 9 (30) | 9 (31) | |
| HTN n (%) | 13 (22) | 7 (23.3) | 6 (20.6) | 0.807 |
| DM n (%) | 16 (27.1) | 6 (20) | 10 (34.4) | 0.211 |
| Chronic lung disease n (%) | 2 (3.3) | 2 (6.6) | 0 (0) | 0.157 |
| HR/min | 95 (89,105) | 92.5 (89,100) | 96 (90,108) | 0.280 |
| Systolic BP (mmHg) | 120 (115,130) | 120 (120,130) | 120 (110,130) | 0.428 |
| Diastolic BP (mmHg) | 80 (70,80) | 80 (70,80) | 80 (70,80) | 0.542 |
| RR /min | 19 (18,22) | 19.5 (18,22) | 19 (18,21) | 0.927 |
| BT (°C) | 37.1 (36.7,37.7) | 37.05 (36.5,37.8) | 37.1 (36.9,37.6) | 0.772 |
| O2 saturation (%) | 88 (85,89) | 88 (85,89) | 88 (85,89) | 0.436 |
| WBC (1000/mm3) | 5.6 (4.6,8.7) | 5.0 (4.2,7) | 6.6 (5,10.9) | 0.026 |
| Neutrophil (%) | 78 (70,83) | 74 (70,80) | 80 (74,87) | 0.114 |
| Lymphocyte (%) | 18 (11,22) | 19 (14,25) | 16 (9,20) | 0.085 |
| Hb (g/dl) | 13.9 (12.4,15) | 13.7 (12.2,15) | 14 (13.1,15.1) | 0.309 |
| Plt (1000/mm3) | 190 (137,226) | 186 (133,220) | 191 (160,234) | 0.457 |
| LDH (U/L) | 591 (444,742) | 545.5 (473,705) | 611 (421,800) | 0.677 |
| BUN (mg/dl) | 34 (27,58) | 30.5 (27,46) | 50 (27,68) | 0.082 |
| Creatinine (mg/dl) | 1.1 (1,1.3) | 1 (0.8,1.1) | 1.2 (1,1.4) | 0.001 |
| K (mEq/L) | 4.1 (3.9,4.4) | 4 (3.9,4.5) | 4.1 (3.9,4.3) | 0.813 |
| Na (mEq/L) | 138 (136,140) | 138 (137,140) | 138 (135,143) | 0.728 |
| ESR | 29 (20,46) | 28 (23,50) | 31 (20,41) | 0.808 |
| AST (U/L) | 31 (21,42) | 34.5 (21,53) | 29 (18,40) | 0.271 |
| ALT (U/L) | 35 (27,45) | 34 (27,42) | 38 (24,47) | 0.596 |
| BS (mg/dl) | 120 (106,174) | 118 (105,141) | 131 (109,229) | 0.295 |
| pH | 7.3 (7.3,7.4) | 7.4 (7.3,7.4) | 7.3 (7.3,7.4) | 0.210 |
| PaO2 (mmHg) | 45 (38,49) | 45 (40,49) | 45 (37,50) | 0.767 |
| PCO2 (mmHg) | 39 (36,45) | 38 (35,42) | 39 (38,47) | 0.084 |
| HCO3 (mEq/L) | 24 (21,26) | 24 (23,26) | 24 (21,26) | 0.522 |
| Duration of stay in ICU (days) | 3 (2,6) | 4 (3,6) | 3 (2,4) | 0.101 |
| Duration of hospitalization (days) | 8 (6,11) | 9 (7,13) | 7 (6,9) | 0.014 |
IVIg Intravenous immunoglobulin, HR Heart rate, BP Blood pressure, RR Respiratory rate, BT Body temperature, WBC White blood cells, HB Hemoglobin, PLT Platelet, LDH Lactate dehydrogenase, BUN Blood urea nitrogen, K Serum potassium, Na Serum sodium, ESR Erythrocyte sedimentation rate, AST Enzymes aspartate transaminase, ALT alanine aminotransferase, ALP Alkaline phosphatase, FBS Fasting blood sugar, BS Blood sugar, PaO2 Partial pressure of oxygen, PCO2 Partial pressure of carbon dioxide, HCO3 Bicarbonate, ICU Intensive care unit
a Data are presented using median (and IQR), except for the following categories (reported as frequency and percentage): sex, HTN, DM, chronic lung disease. $ Comparison between IVIg and control groups