Table 2.
The relationship between study variables and mortality of patients with severe COVID-19
| Mortality | Unadjusted OR (95% CI) | P-value | ||
|---|---|---|---|---|
| No | Yes | |||
| Groups | ||||
| Treatment | 15 (38.4) | 14 (70) | 0.27 (0.08, 0.85) | 0.025 |
| Control | 24 (61.5) | 6 (30) | Ref | |
| Age (years) | 54 (44, 60) | 60 (53.5, 70) | 1.05 (1.01, 1.10) | 0.014 |
| Gender n (%) | ||||
| Male | 27 (70) | 14 (70) | 0.96 (0.30, 3.12) | 0.951 |
| Female | 12 (30) | 6 (30) | Ref | |
| HTN n (%) | 8 (23.3) | 5 (25) | 1.29 (0.36, 4.63) | 0.694 |
| DM n (%) | 11 (20) | 5 (25) | 0.85 (0.25, 2.90) | 0.793 |
| Chronic lung disease n (%) | 1 (6.6) | 1 (5) | 2.00 (0.12, 33.76) | 0.630 |
| HR/min | 95 (90, 100) | 95 (89, 108) | 1.02 (0.96, 1.08) | 0.543 |
| Systolic BP (mmHg) | 120 (120, 130) | 120 (110, 130) | 0.97 (0.93, 1.01) | 0.173 |
| Diastolic BP (mmHg) | 80 (70, 80) | 70 (70, 80) | 0.95 (0.88, 1.01) | 0.120 |
| RR /min | 19 (18, 22) | 20 (18, 22) | 0.98 (0.93, 1.04) | 0.545 |
| BT (C°) | 37.1 (36.7, 37.7) | 37.1 (36.75, 37.65) | 1.26 (0.63, 2.52) | 0.518 |
| O2 saturation (%) | 89 (87, 89) | 85 (80, 88) | 0.84 (0.74, 0.97) | 0.015 |
| WBC (1000/mm3) | 5.1 (4.6, 7.4) | 7.2 (5.1, 11.2) | 1.00 (1.00, 1.00) | 0.743 |
| HB (g/dl) | 13.9 (12.6, 15) | 13.5 (12.05, 15.25) | 0.95 (0.80, 1.13) | 0.566 |
| PLT(1000/mm3) | 210 (135, 247) | 172.5 (139.5, 193) | 1.00 (1.00, 1.00) | 0.090 |
| LDH (U/L) | 520 (400, 687) | 761 (560.5, 1021) | 1.00 (1.00, 1.00) | 0.003 |
| BUN (mg/dl) | 29 (25, 39) | 64 (50, 129.5) | 1.06 (1.02, 1.09) | 0.001 |
| Creatinine (mg/dl) | 1 (1, 1.2) | 1.2 (1.1, 1.55) | 3.63 (0.95, 13.87) | 0.059 |
| K (mEq/L) | 4 (3.7, 4.4) | 4.2 (4.1, 4.3) | 0.95 (0.80, 1.14) | 0.616 |
| Na (mEq/L) | 138 (137, 139) | 138 (135, 143.5) | 1.04 (0.95, 1.14) | 0.344 |
| ESR | 28 (20, 41) | 40 (26, 49.5) | 1.01 (0.99, 1.03) | 0.424 |
| AST (U/L) | 31 (21, 39) | 29.5 (15.5, 52.5) | 1.00 (0.97, 1.02) | 0.735 |
| ALT (U/L) | 34.5 (25, 41) | 38.5 (29.5, 48) | 1.01 (0.99, 1.02) | 0.306 |
| BS (mg/dl) | 119 (105, 174) | 126 (109.5, 184) | 1.00 (0.99, 1.01) | 0.845 |
| PaO2 (mmHg) | 46 (40, 50) | 39.5 (34, 49) | 0.92 (0.85, 0.99) | 0.035 |
| PCO2 (mmHg) | 40 (35, 46) | 38 (36, 39.5) | 0.99 (0.91, 1.08) | 0.798 |
| HCO3 (mEq/L) | 24 (22, 25) | 24.5 (19.5, 26.5) | 1.00 (0.89, 1.13) | 0.946 |
| pH | 7.3 (7.3, 7.4) | 7.3 (7.2, 7.4) | 0.04 (0.00, 8.87) | 0.243 |
Variables with P-value less than 0.2 were selected to enter multivariable regression analysis
IVIg Intravenous immunoglobulin, HR Heart rate, BP Blood pressure, RR Respiratory rate, BT Body temperature, WBC White blood cells, Hb Hemoglobin, Plt Platelet, LDH Lactate dehydrogenase, BUN Blood urea nitrogen, K Serum potassium, Na Serum sodium, ESR Erythrocyte sedimentation rate, AST Enzymes aspartate transaminase, ALT Aka alanine aminotransferase, ALP Alkaline phosphatase, FBS Fasting blood sugar, BS Blood sugar, PaO2 Partial pressure of oxygen, PCO2 Partial pressure of carbon dioxide, HCO3 Bicarbonate, ICU Intensive care unit
aData are presented using median (and IQR) except for the following categories (reported as frequency and percentage): sex, HTN, DM, chronic lung disease, treatment group, control group.