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The working model of 2,3-DCPE in colon cancer cells. 2,3-DCPE induced DNA damage and activated ATM/ATR. S phase arrest was induced by the subsequent phosphorylation of Chk1 and the degradation of Cdc25A. 2,3-DCPE, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol; Chk, checkpoint kinase; ATM, ataxia-telangiectasia mutated; ART, ataxia-telangiectasia and Rad3-related; Cdc25A, M-phase inducer phosphatase 1.
