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. Author manuscript; available in PMC: 2020 Oct 21.
Published in final edited form as: Cell Rep. 2020 Jan 7;30(1):112–123.e4. doi: 10.1016/j.celrep.2019.12.014

Figure 4. CD8CD38high T Cells Express Decreased Levels of EOMES, RUNX3, and T-bet.

Figure 4.

(A) Scheme showing the transcription factors regulating various cytotoxic molecules.

(B) Representative histograms showing EOMES, RUNX3, and T-bet in CD8CD38low and CD38high T cells from a healthy donor by flow cytometry.

(C) MFI from EOMES, RUNX3, and T-bet in CD8CD38low and CD8CD38high T cells from by flow cytometry (healthy subjects ≥3; paired t test).

(D) Percentage of EOMES, RUNX3, and T-bet in CD8CD38low and CD8CD38high T cells by flow cytometry (SLE = 6; paired t test).

(E) mRNA levels of EOMES, RUNX3, and T-bet (TBX21) in CD8CD38low and CD8CD38high T cells by flow cytometry (normal T cells = 10; Kolmogorov-Smirnov test). Cells were sorted by FACS aria.

In all figures, average data are represented as mean ± SD.