Table 2.
Pharmacokinetic parameters of dopamine-loaded nanoparticles after intranasal administration in rats in the brain and blood.
| Formulation | Tissue | Cmax (ng/mL or ng/g) | Tmax (h) | Ke (h−1) | AUC0–12 h (ng.h/mL or ng.h/g) | AUC0–∞ (ng.h/mL or ng.h/g) |
|---|---|---|---|---|---|---|
| NPs | Blood | 160.2 ± 16.5 | 1 | 0.29 ± 0.08 | 686.0 ± 73.4 | 714.5 ± 61.3 |
| Brain | 149.3 ± 21.7 | 1 | 0.15 ± 0.04 | 830.6 ± 108.9 | 1070.0 ± 188.3 | |
| Lf-NPs | Blood | 168.3 ± 17.5 | 1 | 0.29 ± 0.04 | 758.3 ± 116.9 | 784.1 ± 128.8 |
| Brain | 200.4 ± 13.7 | 1 | 0.18 ± 0.07 | 1341.8 ± 109.8* | 1604.0 ± 112.3 | |
| Lf-BNPs | Blood | 175.3 ± 16.8 | 0.5 | 0.37 ± 0.02 | 668.1 ± 102.4 | 675.3 ± 105.2 |
| Brain | 219.4 ± 13.3 | 0.25 | 0.17 ± 0.08 | 1696.4 ± 119.3**# | 1943.8 ± 202.5 |
Values are mean ± SD (n = 3). *p < .05; **p < .01 (versus NP group); #p < .05 (versus Lf-NP group).