Figure 4.

Comparison of IC₅₀ values of CEP or TET between 2D monolayer MDA-MB-231 and MCF-7 cells cultured at different cell numbers. Cells were cultured at cell numbers of 1.0, 2.5 or 5.0×10⁵ cells/ml in the presence of (A) CEP or (B) TET, and the IC₅₀ values were evaluated. The IC₅₀ values of CEP and TET on MDA-MB-231 cells were lower than those of MCF-7 cells. Data are shown as the mean ± SD of >3 independent experiments. *P<0.05 analyzed via one-way ANOVA followed by Sidak's multiple comparisons test. CEP, cepharanthine; TET, tetrandrine.