TABLE 3.
Pharmacokinetics of a single dose of oxfendazole given in fed state or fasted statea
| Parameter | Fasted state (n = 12) | Fed state (n = 12) |
|---|---|---|
| AUClast (ng · h/ml) | 31,600 ± 12,800 | 58,900 ± 15,500 |
| AUC∞ (ng · h/ml) | 34,800 ± 16,000 | 65,400 ± 12,300 |
| Tmax (h) | 1.99 (1.00–2.98) | 8.90 (3.90–11.5) |
| Cmax (ng/ml) | 3,010 ± 1,330 | 4,500 ± 892 |
| t1/2 (h) | 7.65 ± 1.26 | 8.05 ± 0.78 |
| CL/F | 0.0863 ± 0.0352 | 0.0459 ± 0.0096 |
| Vz/F | 0.940 ± 0.339 | 0.531 ± 0.155 |
a
Tmax values are presented as median (range); other parameters are presented as geometric mean ± SD.