TABLE 4.
Changes in oxfendazole pharmacokinetic parameters under fed state versus fasted statea
| Parameter | GM in fasted state | GM in fed state | Ratio of fed/fasted GM | 90% CI of ratio |
|---|---|---|---|---|
| AUClast (ng · h/ml) | 31,600 | 58,900 | 1.86 | 1.64–2.12 |
| AUC∞ (ng · h/ml) | 36,600 | 64,500 | 1.76 | 1.34–2.31 |
| Cmax (ng/ml) | 3,010 | 4,500 | 1.49 | 1.27–1.75 |
| Tmax (h)b | 1.99 | 8.90 | 6.88 | 3.15–7.12 |
a
GM, geometric mean.
b
The values for Tmax are, from left to right, median in fasted state, median in fed state, median difference (h), and 90% CI of median difference (h). The Wilcoxon signed rank test P value was 0.0005.