TABLE 6.
Comparison of oxfendazole, albendazole, and mebendazole pharmacokinetic parameters when drug is administered after an overnight fast or consumption of a fatty meal
| PK parameter | Value for indicated drug and condition |
|||||
|---|---|---|---|---|---|---|
| Oxfendazole (present study) |
Albendazole sulfoxidea
(25) |
Mebendazole (26) |
||||
| Fasted | Fed | Fasted | Fed | Fasted | Fed | |
| Dose | 3 mg/kg (∼200 mg) | 3 mg/kg (∼200 mg) | 400 mg | 400 mg | 500 mg | 500 mg |
| Cmax (ng/ml) | 3,010 | 4,500 | 220 | 1,310 | 14.0 | 56.2 |
| Tmax (h) | 1.99 | 8.90 | 2.25 | 3.75 | 1.5 | 4.0 |
| AUC (ng ⋅ h/ml) | 31,600 | 58,900 | 1,090 | 5,460 | 175 | 456 |
a
Albendazole is rapidly metabolized to its active metabolite albendazole sulfoxide; plasma levels of parent drug are virtually undetectable.