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. 2020 Oct 20;64(11):e01463-20. doi: 10.1128/AAC.01463-20

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Copyright © 2020 Huang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — ABI-H0731 enhances the assembly of aberrant HBV capsids. (A) Effect of increasing concentrations of ABI-H0731 on the oligomerization of Cp150-BODIPY into capsids or other oligomeric structures through fluorescence quenching. The emission of fluorescence was monitored continuously for 1,400 min at 535 nm. (B) Nonlinear regression analysis of the free dimer levels as a function of the ABI-H0731 concentration. (C) Size exclusion chromatography (SEC) analysis of Cp assembly reactions performed in the presence of increasing concentrations of ABI-H0731. (D) Transmission electron microscopy (TEM) of Cp assembly reactions with DMSO (left) and 10 μM ABI-H0731 (middle and right).