. 2020 Oct 20;64(11):e01463-20. doi: 10.1128/AAC.01463-20

TABLE 5.

Activity of ABI-H0731 against HBV Cp variants

HBV Cp substitution	Clinical isolate frequency (%)^a	Fitness (%)	ABI-H0731		NVR 3-778		GLS4		VRD-32		ETV
HBV Cp substitution	Clinical isolate frequency (%)^a	Fitness (%)	Mean EC₅₀ (nM) ± SD	Fold shift	Mean EC₅₀ (nM) ± SD	Fold shift	Mean EC₅₀ (nM) ± SD	Fold shift	Mean EC₅₀ (nM) ± SD	Fold shift	Mean EC₅₀ (nM) ± SD	Fold shift
Wild type		100	146 ± 21	1	178 ± 42	1	17.9 ± 0.4	1	16.1 ± 7.8	1	1.9 ± 0.9	1
P25A	<0.1	122	169 ± 41	1.2	719 ± 58	4	451 ± 3.3	25	15.9 ± 0.04	1	2.9 ± 0.3	1.5
D29G	0.1	19	2,961 ± 917	20	210 ± 52	1.2	16.1 ± 0.4	0.9	13.8 ± 1	0.9	0.6 ± 0.1	0.3
T33N	<0.1	61	3,061 ± 187	21	>10,000	>56	6,345 ± 2,448	350	1,289 ± 242	80	3.5 ± 1.6	1.8
Y38C	0.1	92	224 ± 50	1.5	150 ± 48	0.8	17 ± 9.5	0.9	20 ± 1.4	1.2	1.1 ± 0.5	0.6
Y38F	3.2	55	481 ± 34	3.3	208 ± 49	1.2	65 ± 17	3.7	20 ± 10	1.3	4.6 ± 0.6	2.4
I105L	0.7	73	41 ± 6	0.3	127 ± 73	0.7	12 ± 6.5	0.6	40 ± 19	2.5	0.4 ± 0.2	0.2
I105T	0.6	52	324 ± 20	2.2	726 ± 98	4.1	17 ± 2.7	0.9	103 ± 87	6.4	0.5 ± 0.3	0.4
T109I	0.2	52	>10,000	>68	77.4 ± 0.4	0.4	237 ± 16.6	13	15.8 ± 1.9	1	1.9 ± 0.6	1.0
T109M	0.8	29	>10,000	>68	161 ± 97	0.9	15 ± 5.6	0.9	25 ± 23	1.6	1.5 ± 0.3	0.8
Y118F	0.4	9	2,070 ± 264	14	887 ± 478	5	84.7 ± 2.3	4.7	805 ± 423	50	1.5 ± 0.9	0.8