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ABI-H0731 inhibition of major CYP isoforms in human liver microsomes
| Test article | Test concn (μM) | CYP IC50 (μM) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 1A2 | 2B6 | 2C8 | 2C9 | 2C19 | 2D6 | 3A (MDZa ) | 3A (test) | ||
| ABI-H0731 | 0.1–100 | >100 | 27.7 | 27.2 | 30.7 | 42.8 | 29.6 | 82.3 | 46.2 |
MDZ, midazolam (CYP3A substrate).
