TABLE 3.
Genetic characterization of carbapenem-resistant Providencia sp. isolates
| Isolate | Genome | Plasmid type | Size (bp) | GC content (%) | Antibiotic resistance gene(s) encoding: |
Amino acid substitution(s) in quinolone resistance gene: |
|||
|---|---|---|---|---|---|---|---|---|---|
| Aminoglycoside(s) | β-lactam(s) | GyrA | ParC | GyrB | |||||
| P. rettgeri BML2496 | Chromosome | 4,651,003 | 49.6 | aac(6')-Ib4 | blaIMP-1, blaOXA-1 | Ser83Ile, Asp87Ala | Ser87Ile | ||
| P. rettgeri BML2526 | Chromosome | 4,342,905 | 51.0 | aadA1 | |||||
| Plasmid | IncA/C2 | 204,791 | 50.2 | aac(6')-Iae | blaIMP-70, blaCTX-M-2, blaTEM-1B | Ser83Ile, Asp87Glu | Ser87Ile | Glu468Asp | |
| Plasmid | Nontypeable | 71,575 | 50.5 | ||||||
| P. rettgeri BML2531 | Chromosome | 4,696,377 | 50.1 | ||||||
| Plasmid | IncT | 84,930 | 50.3 | aac(6')-Il | blaIMP-11, blaOXA-2 | Ser83Ile, Asp87Glu | Ser87Ile | ||
| P. rettgeri BML2576 | Chromosome | 4,351,300 | 51.0 | aadA1 | |||||
| Plasmid | IncA/C2 | 204,791 | 50.2% | aac(6')-Iae | blaIMP-70, blaCTX-M-2, blaTEM-1B | Ser83Ile, Asp87Glu | Ser87Ile | Glu468Asp | |
| Plasmid | Nontypeable | 71,575 | 50.5% | ||||||
| P. stuartii BML2537 | Chromosome | 4,418,649 | 49.8% | aac(2')-Ia | |||||
| Plasmid | IncA/C | 152,754 | 50.0% | aac(6')-Iae | blaIMP-70 | Ser83Ile, Asp87Glu | Ser87Arg | ||
| Plasmid | Nontypeable | 30,292 | 50.9% | blaCTX-M-2 | |||||