FIG 6.

MRX-8 and PMB against E. coli ATCC 25922 (top) and P. aeruginosa 3076 (bottom) in the neutropenic mouse pneumonia model. Groups of 3 mice were infected with the select organism and treated for 24 h with MRX-8 at 35 mg/kg/12 h or PMB at 25 mg/kg/12 h by the subcutaneous route. The dashed horizontal line is the initial burden. Blue vertical bars represent growth in the untreated control. The difference at 24 h between MRX-8- and PMB-treated mice was statistically significant (*, P < 0.001 by Student’s t test).