TABLE 1.
MIC distributions for meropenem, alone and combined with QPX7728 at various concentrations, and comparator antibiotics against 275 carbapenem-resistant strains of A. baumannii (n = 268) and A. nosocomialis (n = 7)
| Drug(s)a | % inhibited at MIC (μg/ml) of: |
MIC50 (μg/ml) | MIC90 (μg/ml) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | >64 | |||
| MER | ||||||||||||||
| Alone | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.5 | 3.6 | 14.9 | 46.9 | 78.2 | 100 | 64 | >64 |
| W/QPX 1 μg/ml | 0.4 | 0.4 | 0.7 | 1.5 | 2.2 | 7.3 | 18.5 | 38.2 | 56.4 | 72.7 | 88.7 | 100 | 16 | >64 |
| W/QPX 2 μg/ml | 0.7 | 1.1 | 1.5 | 6.2 | 15.6 | 32.0 | 57.5 | 74.2 | 89.8 | 96.4 | 98.2 | 100 | 4 | 32 |
| W/QPX 4 μg/ml | 1.1 | 1.8 | 4.7 | 16.4 | 33.1 | 60.4 | 80.0 | 94.5 | 99.3 | 100 | 100 | 100 | 2 | 8 |
| W/QPX 8 μg/ml | 5.8 | 12.4 | 24.7 | 34.2 | 56.4 | 75.6 | 91.3 | 98.5 | 100 | 100 | 100 | 100 | 1 | 4 |
| W/QPX 16 μg/ml | 33.1 | 39.3 | 50.2 | 65.5 | 77.1 | 86.9 | 97.5 | 100 | 100 | 100 | 100 | 100 | 0.25 | 4 |
| LVFX | 0.4 | 0.4 | 0.4 | 0.7 | 1.5 | 2.2 | 6.5 | 24.4 | 56.4 | 74.2 | 89.5 | 100 | 16 | >64 |
| MINO | 0.0 | 0.0 | 0.4 | 4.0 | 16.4 | 28.7 | 36.7 | 50.5 | 82.5 | 97.1 | 99.6 | 100 | 8 | 32 |
| TIG | 0.0 | 1.1 | 2.5 | 4.7 | 15.6 | 42.2 | 84.0 | 94.5 | 99.6 | 100 | 100 | 100 | 4 | 8 |
| SUL | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.1 | 4.4 | 11.6 | 26.2 | 61.1 | 88.4 | 100 | 32 | >64 |
| PmB | 0.0 | 0.0 | 1.8 | 30.5 | 74.9 | 88.0 | 91.3 | 93.8 | 96.0 | 97.5 | 99.3 | 100 | 1 | 4 |
a
MER, meropenem; QPX, QPX7728; LVFX, levofloxacin; MINO, minocycline; TIG, tigecycline; SUL, sulbactam; PmB, polymyxin B; W/, with.