TABLE 3.
Pharmacokinetic parameters used for the simulations
| Drug by organism | k01a (1/h) | k10b (1/h) | V/Fc (liter/kg) | Vd (liter) | Protein binding (%) | Reference(s) |
|---|---|---|---|---|---|---|
| Human | ||||||
| Aztreonam | 0.433 | 12.6 | 56 | 29 | ||
| Biapenem | 0.594 | 18.5 | 7 | Unpublished, 30 | ||
| Cefepime | 0.400 | 18.0 | 20 | 31 | ||
| Ceftazidime | 0.381 | 18.1 | 5 | 32 | ||
| Ceftolozane | 0.408 | 13.3 | 20 | 33 | ||
| Meropenem | 0.743 | 20.2 | 2 | 34 | ||
| Mouse | ||||||
| Aztreonam | 28.56 | 2.37 | 0.48 | 56.5 | This manuscript, 35 | |
| Biapenem | 16.38 | 3.16 | 0.30 | 2 | This manuscript, 30 | |
| Cefepime | 16.00 | 2.24 | 0.50 | 0 | 25–27 | |
| Ceftazidime | 9.51 | 4.37 | 0.40 | 0 | This manuscript, 36 | |
| Ceftolozane | 3.00 | 3.09 | 0.43 | 5 | 28 | |
| Meropenem | 13.73 | 3.61 | 0.57 | 10 | This manuscript, 37 |
a
k01, absorption rate constant.
b
k10, elimination rate constant.
c
V/F, volume of distribution/fraction absorbed.
d
V, volume of distribution.