TABLE 4.

Comparison of the 24-h free AUC and %24h ƒT>MIC of each beta-lactam in mice and in humans

Drug	Species	Dosage regimena	%24h ƒT>MIC at MIC (mg/liter) of:										24-h free AUC mg*h/liter
			128	64	32	16	8	4	2	1	0.5	0.25
Aztreonam	Human	2,000 mg TID by 1-h infusion	0	0	22.5	45	66.9	88.6	100	100	100	100	484
	Mouse	150 mg/kg q2h	6	22	38	52.5	67	81.5	96.5	100	100	100	894
Biapenem	Human	1,000 mg TID by 3-h infusion	0	0	0	27.5	60	74.4	88.6	100	100	100	254
	Mouse	100 mg/kg q2h	16.5	29	40	50	62	73	84	95	100	100	1,229
Cefepime	Human	2,000 mg TID by 2-h infusion	0	0	34.1	61.8	88.6	100	100	100	100	100	667
	Mouse	150 mg/kg q2h	20	36.5	50.0	68.5	84	100	100	100	100	100	1,607
Ceftazidime	Human	2,000 mg TID by 2-h infusion	0	8.8	41.9	70.6	97.5	100	100	100	100	100	826
	Mouse	300 mg/kg q2h	25	41	55.5	69.5	83.5	98.0	100	100	100	100	1,809
Ceftolozane	Human	2,000 mg TID by 1-h infusion	0	17.5	44.3	68.2	88.8	100	100	100	100	100	884
	Mouse	150 mg/kg q2h	0	38	59	74.5	88.5	100	100	100	100	100	1,287
Meropenem	Human	2,000 mg TID by 3-h infusion	0	0	18.8	44.4	60.0	75.1	87.1	100	100	100	392
	Mouse	300 mg/kg q2h	20	30	41.5	51	60.5	70	79	89	100	100	1,575

^aq2h, every 2 hours; TID, three times a day.