TABLE 1.
Drug susceptibility/resistance profile of smooth and rough variants derived from the reference M. abscessus 104536T strain to various rifamycins in CaMBHb
| Strain | Morphotype | MIC (μg/ml)a
|
|||
|---|---|---|---|---|---|
| RFB | RIF | RPT | RFX | ||
| CIP104536 (S) | S | 64 | >128 | >128 | >128 |
| CIP104536 (R) | R | 16 | >128 | >128 | >128 |
| ΔMAB_mmpL4b | R | 16 | >128 | >128 | >128 |
| ΔMAB_mmpL4b_C | S | 32 | >128 | >128 | >128 |
| CIP104536 (S) + pMV306-MAB_1409c-HA | S | 64 | >128 | >128 | >128 |
| CIP104536 (R) + pMV306-MAB_1409c-HA | R | 64 | >128 | >128 | >128 |
a
MICs (μg/ml) were determined following the CLSI guidelines.
b
RFB, rifabutin; RIF, rifampin; RPT, rifapentine; RFX, rifaximin.