TABLE 1.
MIC distributions of aztreonam-avibactam and comparator agents tested against Stenotrophomonas maltophilia isolates collected worldwide (2016–2019)
| Antimicrobial agent | No. of isolates (cumulative %) inhibited at a MIC (mg/liter) of: |
MIC (mg/liter) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >a | 50% | 90% | |
| Aztreonam-avibactam | 0 (0.0) | 1 (0.1) | 3 (0.2) | 12 (0.9) | 132 (8.0) | 766 (49.7) | 780 (92.1) | 105 (97.8) | 16 (98.7) | 24 (100.0) | 4 | 4 | |
| Ceftazidime | 0 (0.0) | 1 (0.1) | 0 (0.1) | 0 (0.1) | 26 (1.4) | 113 (7.6) | 115 (13.8) | 131 (20.9) | 148 (29.0) | 240 (42.0) | 1,066 (100.0) | >32 | >32 |
| Colistin | 8 (0.4) | 77 (4.6) | 194 (15.2) | 164 (24.1) | 159 (32.7) | 160 (41.4) | 257 (55.4) | 287 (71.0) | 533 (100.0) | 4 | >8 | ||
| Levofloxacin | 0 (0.0) | 1 (0.1) | 45 (2.5) | 326 (20.2) | 709 (58.8) | 354 (78.0) | 173 (87.4) | 231 (100.0) | 1 | >4 | |||
| Moxifloxacin | 736 (42.9) | 404 (66.5) | 238 (80.3) | 132 (88.0) | 94 (93.5) | 111 (100.0) | 0.5 | 4 | |||||
| Minocycline | 0 (0.0) | 1 (1.0) | 11 (11.7) | 65 (74.8) | 15 (89.3) | 5 (94.2) | 5 (99.0) | 1 (100.0) | 0.5 | 2 | |||
| Tigecycline | 1 (0.1) | 5 (0.3) | 94 (5.4) | 464 (30.7) | 633 (65.1) | 366 (85.0) | 179 (94.8) | 85 (99.4) | 11 (100.0) | 1 | 2 | ||
| TMP-SMXb | 1,646 (89.7) | 60 (92.9) | 45 (95.4) | 29 (96.9) | 56 (100.0) | ≤0.5 | 1 | ||||||
a
Greater than the highest dilution tested.
b
TMP-SMX, trimethoprim-sulfamethoxazole.