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Fitted parameters
| Parameter | Unit | Value | %RMSE | Description |
|---|---|---|---|---|
| Zr_0_free | Mole | 2.2E-9 | (8.6) | Free 89Zr or 89Zr-GSK3128349 AlbudAb fragments in the dose* |
| Koff_Zr | 1/h | 9.1E-5 | (10) | 89Zr dissociation from DFO chelate |
| Qurn_Zr | ml/h | 0.11 | (3) | Clearance of 89Zr label into urine from the glomerular compartment |
| J_br | Dimensionless | 1.1E-6 | (21) | Fractional lymph flow rate in the brain |
| br_mp | Dimensionless | 1.1E-8 | (18) | Macropinocytosis rate adjustment in the brain |
*computationally estimated value
