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. Author manuscript; available in PMC: 2021 Oct 14.
Published in final edited form as: Neuron. 2020 Oct 14;108(1):93–110. doi: 10.1016/j.neuron.2020.09.003

Figure 5 -. Acoustically Targeted Pharmacology and Chemogenetics.

Figure 5 -

(A) Illustration of microbubble-mediated blood brain barrier (BBB) opening by focused ultrasound. (B) Left: illustration of drug release from propofol-loaded nanoemulsions (adapted from Airan et al., 2017). Middle: illustration of ultrasound focal zone. Right: Fluorodeoxyglucose Positron emission tomography (FDG PET) images captured during sonication with or without propofol-loaded nanoparticle administration are shown. Scale bar, 5 mm (adapted from Wang et al., 2018). (C) Schematic of acoustically targeted chemogenetics (ATAC) paradigm. (D) Representative MRI scan indicating the site of the BBB opening (top, scale bar: 1 mm) and immunostaining imaging (bottom, scale bar: 200 μm). AAVs encoding hMsDq-mCherry were selectively delivered to the left SNc/VTA. The targeted neurons were excited by clozapine-N-oxide (CNO) ( C and D adapted with permission from Szablowski et al., 2018).