Skip to main content
. Author manuscript; available in PMC: 2020 Oct 21.
Published in final edited form as: J Invest Dermatol. 2018 Jun;138(6):1249–1251. doi: 10.1016/j.jid.2018.02.020

Figure 1. Proposed modes of action of IVIG in BP.

Figure 1.

The mechanisms of IVIG as a therapeutic include the saturation of the IgG protective neonatal FcR receptor (FcRn); the neutralization of autoantibodies by anti-idiotypic antibodies;the neutralization cytokines or modulation of cytokine production; the attenuation of complement-mediated tissue damage; the modulation of functions and expression of the IgG receptors FcγRs; and the modulation of effector functions of T, B and dendritic cells. In mouse models of BP, IVIG are protective through the saturation of FcRn and anti-idiotypic antibodies to reduce circulating pathogenic IgG levels and by modulation of IL-6 and IL-10 production.