Table 1.

Modified histopathologic score parameters (16).

Histologic appearance	Score	Type / Localization
Steatosis	0: < 5% 1: 5–33% 2: > 33–66% 3: > 66%	Macrovesicular, microvesicular or mixed Zone 1, 2, 3
Hepatocellular Ballooning	0: None 1: Few balloon cells 2: Many cells/ prominent ballooning	Hydropic degeneration
Inflammatory foci per 200× field, mean of 3 fields (NAS)	0: 0 1: < 2 2: 2–4 3: > 4	Lobular or portal
Fibrosis	0: None 1: Perisinusoidal or periportal 2: Perisinusoidal and portal/ periportal 3: Bridging 4: Cirrhosis	Subgroups of score 1: 1A: Mild, zone 3, perisinusoidal 1B: Moderate, zone 3, perisinusoidal 1C: Portal/ periportal
PAS positive staining	0: − −1: + 2: ++ 3: +++	Zone 1, 2, 3