Fig 5. Inference on the transcription model.

A: Schematic representation of the gene expression model. The model consists of a gene that switches between an “on” and an “off” state with rates k_on and k_off. When “on” the gene is getting transcribed at rate k_r. The transcription process is modelled through n RNA species that sequentially transform from one to the next at rate λ. The observed species are all of the intermediate RNA_i species. B: The marginal posterior distribution of the parameters of the system. The histogram indicates the posterior obtained through LF-NS, the blue line indicates the posterior obtained from a long pMCMC run and the shaded areas indicate the parameter ranges that were considered in [58]. The scale of the x-axis does not represent the range of the prior and has been chosen for presentational purposes. C: The five trajectories used for the parameter inference.