FIG. 3:

Phyto-β-SERM diet promoted spatial working memory function. Three-month-old female mice were OVX or sham-OVX and fed one of the three test diets: a phytoestrogen-free control diet, a phyto-β-SERM formulation-containing diet or a commercial soy extract-containing diet, for 9 months. After 8.5-month treatment, a cognitive behavioral test of spatial working memory function, Y-Maze, was administered. In the one-trial test of SAB, the total number and the order of arm entries were recorded. In the two-trial recognition memory test that consisted of an acquisition trial followed by a retention trial, the first entry, the number of entries into each arm and the amount of time spent in the novel arm were recorded. Data are presented as percent of phytoestrogen-free diet-treated sham-OVX control group and expressed as group mean ± S.E.M.; N / group = 5-7. * P < 0.05 and ** P < 0.01.