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. Author manuscript; available in PMC: 2020 Oct 21.
Published in final edited form as: Menopause. 2011 Oct;18(10):1131–1142. doi: 10.1097/gme.0b013e3182175b66

Table 4.

Phyto-β-SERM vs soy extract formulations.

Phyto-β-SERM Formulation Soy Extract Formulation
Compositional Complexity Rationally designed and has a standardized composition Varied in compositional complexity and are not standardized in composition
Phytoestrogens/Equol Genistein, daidzein and equol Genistein/genistin, daidzein/daidzin, glycitein/glycitin, and possibly other structurally similar chemicals; w/o equol
ERα/β Specificity ERβ agonism ERα/β agonism & antagonism
Efficacy/Safety ERβ-medicated estrogenic activities; ERα-mediated proliferative effect on the reproductive system is minimal Unpredictable