Table 2:
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
| ||||||
Variable | OR | 95%CI | P-value | OR | 95%CI | P-value |
Testing cohort | ||||||
Age ≧ 69 | 1.87 | 0.57-6.82 | 0.31 | |||
Male | 1.16 | 0.35-4.24 | 0.81 | |||
Macroscopical type 3 or 4 | 7.91 | 1.91-54.27 | 0.003 | 6.83 | 1.45-50.61 | 0.01 |
Tumor size >55mm | 2.19 | 0.66-7.99 | 0.2 | |||
Poorly differentiated histology | 2.05 | 0.60-8.28 | 0.26 | |||
MiRNA combined signature high risk | 13.12 | 3.12-90.96 | 0.0002 | 11.74 | 2.61-84.97 | 0.0008 |
| ||||||
Validation cohort | ||||||
Age ≧ 70 | 0.54 | 0.15-1.72 | 0.3 | |||
Male | 1.44 | 0.40-6.84 | 0.6 | |||
Macroscopical type 3 or 4 | 4.73 | 1.34-22.26 | 0.01 | 4.97 | 1.20-26.99 | 0.03 |
Tumor size >55mm | 4.73 | 1.34-22.26 | 0.01 | 6.63 | 1.62-35.88 | 0.007 |
Poorly differentiated histology | 2.76 | 0.86-9.80 | 0.09 | |||
MiRNA combined signature high risk | 14.15 | 2.60-263.78 | 0.0007 | 17.52 | 2.89-343.90 | 0.0007 |
| ||||||
Performance evaluation cohort | ||||||
Age ≧ 69 | 1.48 | 0.77-2.88 | 0.24 | |||
Male | 0.81 | 0.38-1.77 | 0.58 | |||
Macroscopical type 3 or 4 | 5.82 | 2.74-13.59 | <0.0001 | 6.44 | 2.76-16.51 | <0.0001 |
Tumor size >55mm | 3.25 | 1.64-6.72 | 0.0006 | 2.24 | 1.03-5.01 | 0.04 |
Poorly differentiated histology | 2.31 | 1.13-5.07 | 0.02 | 1.73 | 0.76-4.17 | 0.19 |
MiRNA combined signature high risk | 3.56 | 1.82-7.09 | 0.0002 | 5.22 | 2.42-11.80 | <0.0001 |
OR, Odds Ratio; CI, Confidence Interval. Bold indicates a statistically significant.