Table 1.
Baseline characteristics and covariates overall and by hypertension trend (at midlife, baseline exam)
| Hypertension Trend Category | ||||
|---|---|---|---|---|
| Characteristic | All | Normal-Normal (N-N) | Normal-Hypertensive (N-H) | Hypertensive-Hypertensive (H-H) |
| N (%) | 1686 (100%) | 770 (46%) | 505 (30%) | 411 (24%) |
| Age, mean (SD), y | 52 (9) | 49 (9) | 53 (8) | 56 (8) |
| Men, n (%) | 780 (46) | 306 (40) | 248 (49) | 226 (55) |
| Systolic Blood Pressure, mm Hg | 122.7 (17.5) | 111.5 (10.7) | 123.3 (9.5) | 142.9 (17.0) |
| Diastolic Blood Pressure, mm Hg | 74.4 (10.2) | 69.6 (8.0) | 74.8 (7.8) | 83.1 (10.6) |
| Diabetes mellitus | 78 (5) | 13 (2) | 20 (4) | 45 (11) |
| Cigarette smoking | 288 (17) | 144 (19) | 95 (19) | 49 (12) |
| Prevalent cardiovascular disease | 66 (4) | 14 (2) | 22 (4) | 30 (7) |
| Statin use | 38 (3) | 9 (1) | 13 (3) | 16 (5) |
| Atrial Fibrillation | 11 (1) | 2 (0) | 5 (1) | 4 (1) |
| Antihypertensive medication | 191 (11) | 0 (0) | 0 (0) | 191 (47) |
| ApoE4 (any allele) | 366 (22) | 164 (22) | 103 (21) | 99 (25) |
| Antiplatelet therapy | 2 (0) | 0 (0) | 0 (0) | 2 (1) |
| Anticoagulant therapy | 4 (0) | 0 (0) | 3 (1) | 1 (0) |
| At follow-up (late life) | ||||
| Any CMB, n (%) | 140 (8) | 44 (6) | 41 (8) | 55 (13) |
| Any CBI, n (%) | 221 (13) | 74 (10) | 66 (13) | 81 (20) |
Values are mean (SD) for continuous variables, and counts (%) for categorical variables.
CMB = cerebral microbleeds. CBI = covert brain infarcts.