Figure 1.

LTP in the left and right BLA of PND22-PND28 animals. Plots of evoked fEPSP slope against time are normalized to baseline for each recording. Representative traces below each plot were obtained 2 min before (left traces) and 25 min after HFS (right traces). A, B, In males, LB enhanced LTP in the right BLA only. C, D, There was no effect of LB-rearing on LTP formation in females in either the left or right BLA. E, Representative trace of evoked fEPSP before (top) and after the blockade of AMPARs by DNQX (middle). This trace is overlapped in the bottom. Red represents after DNQX treatment. Fiber volley (fv) of the trace was insensitive to the DNQX blockade. F, G, LTP as a function of percent of baseline in NB or LB male and female groups in the right and left BLA 25-30 min after HFS. LB male pups displayed significantly enhanced LTP compared with NB males and LB females in the right BLA only. Two-way ANOVAs with bedding and sex as between-subject factors were performed and followed by simple effects tests to decompose significant interactions. Data are mean ± SEM of n = 9-11 slices/group, 5-8 animals/group. **p < 0.01. ***p < 0.001.