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. 2020 Oct 21;40(43):8214–8232. doi: 10.1523/JNEUROSCI.0604-20.2020

Figure 2.

Figure 2.

Sel1L cKO mice developed adult-onset myelin loss in the spinal cord, and PERK inactivation in oligodendrocytes rescued myelin loss in the spinal cord of adult Sel1L cKO mice. MBP IHC showed that the immunoreactivity of MBP was not significantly changed in the spinal cord of 3-, 5-, and 6-week-old Sel1L cKO mice compared with WT mice (A–C,K–M), but was noticeably reduced in the spinal cord of 10-, 16-, and 24-week-old Sel1L cKO mice compared with WT mice (D–F,N–P). The immunoreactivity of MBP was comparable in the spinal cord of 3-, 6-, 16-, and 24-week-old PERK cKO mice and WT mice (A–J). Moreover, the immunoreactivity of MBP was not significantly changed in the spinal cord of 3- and 6-week-old double cKO mice compared with Sel1L cKO mice, PERK cKO mice, and WT mice (A,C,G,H,K,M,Q,R). Importantly, the immunoreactivity of MBP was noticeably increased in the spinal cord of 16- and 24-week-old double cKO mice compared with Sel1L cKO mice (O,P,S,T).