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. 2020 Oct 21;6(43):eabc3020. doi: 10.1126/sciadv.abc3020

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5 — (A) Schematic view of the ZNF75D gene locus. (B) Expressional correlation between ZNF75D and an upstream HERV (THE1D-int) in tumors. (C) Effect of the HERV integrant on the promoter activity of ZNF75D. The effect was assessed by a luciferase reporter assay in A549 cells. A pair of reporter plasmids harboring the ZNF75D promoters with and without the HERV were constructed, and subsequently, the promoter activities were compared. Error bars indicate the SEM. (D) Effect of CRISPR-Cas9 excision of the HERV on the expression of ZNF75D in A549 cells. The mRNA expression level of ZNF75D in each clone of cells was measured by qRT-PCR. The P value was calculated using linear regression.