Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 21;6(43):eabb3063. doi: 10.1126/sciadv.abb3063

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 2 — (A) The minor allele (A allele, MAF = 0.41) of rs708384 was significantly associated with lower CSF levels of PGRN in a dose-dependent manner. (B) CSF PGRN levels were compared across the AA, AC, and CC genotypes of rs708384 in a larger independent cohort of 930 nondemented Chinese participants to validate the initial observed top signal. A significant association of decreasing CSF PGRN levels with increased minor allele (A) dose of rs708384 was observed, independent of age, gender, education, APOE ε4 genotype, MMSE score at baseline, CV, and rs5848 genotype.