Table 1. Characteristics of discovery and replication samples.
CV, coefficient of variation.
| ADNI (discovery sample) | CABLE (replication sample) | ||||||
| Baseline diagnosis | Total | HC | MCI | Total | AA | AC | CC |
| n | 432 | 157 | 275 | 930 | 93 | 392 | 445 |
| Age, years, mean ± SD | 72.8 ± 6.8 | 74.7 ± 5.5 | 71.8 ± 7.3 | 62.6 ± 10.4 | 62.1 ± 9.9 | 62.9 ± 10.2 | 62.4 ± 10.7 |
| Male/female, n | 252/180 | 85/72 | 167/108 | 380/550 | 46/47 | 157/235 | 177/268 |
| Education, years | 16.2 ± 2.8 | 16.4 ± 2.8 | 16.0 ± 2.8 | 9.7 ± 5.2 | 10.6 ± 10.1 | 9.5 ± 4.5 | 9.7 ± 4.2 |
| APOE Ɛ4 carrier, % | 37.5% | 22.3% | 46.5% | 16.3% | 15.05% | 17.98% | 16.34% |
| CSF PGRN, mean ± SD, pg/ml | 1600.3 ± 612 | 1551.2 ± 368.6 | 1628.4 ± 713.9 | 1739 ± 372 | 1687 ± 453 | 1696 ± 335 | 1787 ± 380 |
| CV of CSF PGRN, mean ± SD, % | 2.3 ± 1.7 | 2.4 ± 1.9 | 2.2 ± 1.7 | 2.95 ± 2.69 | 2.74 ± 2.40 | 2.90 ± 2.71 | 3.04 ± 2.72 |