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. 2020 Oct 21;6(43):eaaz4452. doi: 10.1126/sciadv.aaz4452

Fig. 1. HSB-1–associated life-span extension is suppressed by knockdown of histone H4.

Fig. 1

(A to C) Life-span analysis of wild-type (N2) and hsb-1(−) worms subjected to control, his-67, his-5, or his-38 RNAi at 25°C. (D and E) Immunoblots for core histones in N2 and hsb-1(−) worms subjected to control, his-67, his-5, or his-38 RNAi at 25°C. Means ± SEM for n ≥ 3. *P < 0.05 compared to corresponding control RNAi in two-tailed t test. (F) Life-span analysis of N2 and sur-5p::hsf-1 overexpression strain subjected to control or his-38 RNAi at 25°C. (A to C and F) Statistical data and additional life-span replicates are included in table S1.