Extended Data Table. PIK3CA variant modeling survival statistics.
Statistics for survival study of PIK3CA variants in 2xCr background. 3xCr model served as a positive control. All studies were terminated at 1 year of age. p-values were calculated using the log rank test. * denoted studies with surviving mice because the study was ended before they died.
| Count | Survival Range (days) | p-values (log rank test) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Total | ♂ | ♀ | First death | Last death | Median | 2×Cr; H1047R |
2×Cr; M10431 |
2×Cr; H701P |
2×Cr; V638A |
2×Cr; E545K |
2×Cr; C420R |
2×Cr; R88Q |
2×Cr; PIK3CA |
2×Cr; Cherry |
| 3×Cr | 42 | 23 | 19 | 53 | 105 | 84 | 0.000129 | 0.137233 | 7.49E-11 | 1.73E-10 | 0.000733 | 1.61E-15 | 0.000605 | i 6.65E-13 | 2.28E-13 |
| 2×Cr; Cherry | 28 | 12 | 16 | 115 | 351 | 203 | 4.51E-13 | 1.54E-12 | 0.000378 | 0.606653 | 2.56E-13 | 9.73E-15 | 6.69E-11 | 0.000469 | |
| 2×Cr; PIK3CA | 29 | 16 | 13 | 50 | 252 | 150 | 3.62E-13 | 6.34E-10 | 4.41 E-09 | 0.00151 | 3.10E-13 | 1.02E-15 | 1.61E-06 | ||
| 2×Cr; R88Q | 21 | 11 | 10 | 39 | 155 | 103 | 2.54E-05 | 0.067048 | 1.43E-10 | 2.36E-08 | 9.78E-05 | 2.71 E-08 | |||
| 2×Cr; C420R | 20 | 12 | 8 | 22 | 84 | 44 | 0.008385 | 8.79E-08 | 1.30E-11 | 1.60E-11 | 0.001131 | ||||
| 2×Cr; E545K | 32 | 17 | 15 | 37 | 119 | 63 | 0.398171 | 0.001046 | 9.81 E-11 | 2.49E-10 | |||||
| 2×Cr; V638A | 20 | 11 | 9 | 99 | >365* | 203 | 3.90E-10 | 4.38E-09 | 0.000867 | ||||||
| 2×Cr; H701P | 20 | 12 | 8 | 200 | >365* | 273 | 1.79E-10 | 1.17E-26 | |||||||
| 2×Cr; M10431 | 19 | 12 | 7 | 51 | 134 | 80 | 0.000236 | ||||||||
| 2×Cr: H1047R | 30 | 13 | 17 | 32 | 115 | 59 | |||||||||