Table 2.
Univariable Cox proportional hazard model for survival after recurrence
| Overall cohort |
||
|---|---|---|
| Adjusted HRa) (95% CI) | p-value | |
| Age | 1.007 (1.001-1.013) | 0.025 |
| Sex | 0.362 | |
| Male | 1 | |
| Female | 1.072 (0.923-1.246) | |
| Serosa invasion | 0.001 | |
| Negative | 1 | |
| Positive | 1.324 (1.128-1.555) | |
| LN metastasis | 0.325 | |
| Negative | 1 | |
| Positive | 1.141 (0.878-1.482) | |
| TNM stage | 0.004 | |
| II | 1 | |
| III | 1.288 (1.086-1.527) | |
| Lauren classification | < 0.001 | |
| Intestinal | 1 | |
| Diffuse/Mixed | 1.470 (1.264-1.708) | |
| Tumor location | 0.202 | |
| UB/Whole | 1 | |
| MB/LB | 1.135 (0.934-1.378) | |
| MSI/MMR | 0.290 | |
| MSS/pMMR | 1 | |
| MSI-H/dMMR | 1.155 (0.885-1.506) | |
| Adjuvant CTx | 0.176 | |
| No | 1 | |
| Yes | 0.894 (0.760-1.052) | |
| Interval to recurrence (yr) | < 0.001 | |
| < 1 | 1 | |
| ≥ 1, < 2 | 0.768 (0.647-0.912) | 0.003 |
| ≥ 2 | 0.650 (0.545-0.776) | < 0.001 |
| Type of recurrence | < 0.001 | |
| Locoregional | 1 | |
| Hematogenous | 1.010 (0.793-1.288) | 0.935 |
| Peritoneum | 1.434 (1.163-1.768) | 0.001 |
| Any combination | 1.603 (1.256-2.045) | < 0.001 |
| Krukenberg only | 0.614 (0.393-0.961) | 0.033 |
| CTx after recurrence | < 0.001 | |
| No | 1 | |
| Yes | 0.363 (0.306-0.431) | |
HR, hazard ratio; CI, confidence interval; LN, lymph node; UB, upper body; MB, mid-body; LB, lower body; MSI, microsatellite instability; MMR, mismatch repair; MSS, microsatellite stable; pMMR, proficient mismatch repair; MSI-H, microsatellite instability high; dMMR, deficient mismatch repair; CTx, chemotherapy.
a)
Adjusted by institution.